Malignancy of tumors is threatening without a doubt. FAP or Familial Adenomatous Polyposis is a condition that needs some limelight shared. To begin with, it is an inherited disorder that springs up due to multiple growth of adenomatous polyps in the epithelium of organs like the large intestine. Rectum is undeniably a prime targeted region. Genetic mutation is assigned as the root cause of this grave disease. It stems out the count of tumor suppressor genes in the body. This naturally takes down the body’s ability to defend and rule out surplus growth of tumors in the area. Results? Old fibrous growths age and turns cancerous in no time.
Colorectal cancer is absolutely treatable. What’s important is to diagnose the problem at the earliest and ward-off unwanted growths of polyps. A classic aftermath of familial adenomatous polyposis is the amplification in the count of polyps with age. The fibrous growths, certainly non-cancerous and termed as desmoid tumors first pop up in the tissues covering the intestines. Gradually, it fans out to the nearby organs like the small intestine, stomach, on the skin and surrounding other tissues.
Before delving any further, learning about the types of the disorder is worth the time.
First, Attenuated FAP. It is a condition that prevails due to the defect of APC genes in chromosome 5.
Second, Autosomal Recessive Familial Adenomatous Polyposis. Calling it a milder type of the traditional FAP is appropriate. It highlights flaw in the MUTYH genes on chromosome 5. In this case, it is needful that both parents must be carriers.
Last in the list is FAP – one of the severe and ultimate stage of colonic polyps.
Commonly Observed Symptoms:
Frankly, the initial symptoms of colorectal cancer are silent. Hundreds and thousands of fibrous tumors pop up silently, reckoned as colorectal polyps. Discomfort in the intestinal tract can be studied as a primary symptom. Blood discharge in stools is pretty common. At times, it is okay if no sort of bleeding is witnessed. In such scenario, patients targeted with FAP may start developing baneful iron deficiency leading to anemia.
Once the tumors turn malignant, possible symptoms like unexpected weight loss, changed bowel habits and metastasis can occur. Thinking what metastasis is all about? Well, it refers to the spread of malignancy and other diseases from organs to other parts in the body without necessarily being linked anyway.
Polyp in the rectum – a sure shot symptom of FAP. Is that it? Unfortunately, not! Based on the intensity of flaw in the APC (Adenomatous Polyposis coli) gene, tumors can pop up like mushrooms in the intestinal tract, colon, duodenal tract, stomach and anywhere else. Not spotting polyps in the rectum does not confirm absolute extinction of FAP.
FAP Voice – A relief for the patients if Familial Adenomatous Polyposis.
Not to be forgotten but FAP is a rare inherited disorder. FAPvoice play a brilliant role by working as a virtual online community for all affected patients anywhere across the globe. The portal is home to expert physicians, nutritional counselors and specialists curing genetic disorders. Plethora of information related to the disease, its symptoms, prevention mechanisms, diagnosis and stages to truck through for quick relief – everything you need to know is covered in the portal. Quite a massive help for the convalescents of FAP, right?